|
|
L-glutamate + 7,8-dihydropteroate + ATP <=> H+ + 7,8-dihydrofolate + phosphate + ADP
|
6.3.2.12
dihydrofolate synthase
6.3.2.17
tetrahydrofolate synthase
|
–
–
|
BMK
|
|
BRENDA:
BR104
KEGG:
R02237
MetaCyc:
DIHYDROFOLATESYNTH-RXN
|
|
|
|
7,8-dihydrofolate + formate + ATP <=> N10-formyltetrahydropteroylglutamate + phosphate + ADP
|
6.3.4.17
formate---dihydrofolate ligase
|
–
|
|
|
BRENDA:
BR138
KEGG:
R02238
MetaCyc:
FORMATE--DIHYDROFOLATE-LIGASE-RXN
|
|
|
|
tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
1.5.1.50
dihydromonapterin reductase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BR36900
KEGG:
R00939
MetaCyc:
DIHYDROFOLATEREDUCT-RXN;
RXN-19329
|
|
|
|
5,10-methylenetetrahydrofolate + dCMP <=> 7,8-dihydrofolate + 2''-deoxy-5-methylcytidylate
|
2.1.1.45
thymidylate synthase
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
–
|
|
|
BRENDA:
BR40556
KEGG:
R01670
MetaCyc:
DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN
SABIO-RK:
1796
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate
|
2.1.1.45
thymidylate synthase
|
–
|
BMK
|
|
BRENDA:
BR43900;
BS319728
KEGG:
R02101
MetaCyc:
THYMIDYLATESYN-RXN
SABIO-RK:
88
|
|
|
|
7,8-dihydrofolate + NADH + H+ <=> tetrahydrofolate + NAD+
|
1.5.1.3
dihydrofolate reductase
|
–
|
K
|
|
BRENDA:
BS424618
KEGG:
R00936
SABIO-RK:
1254
|
|
|
|
7,8-dihydrofolate + NADP+ <=> folate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
|
–
–
|
K
|
|
KEGG:
R02236
MetaCyc:
RXN-18357
SABIO-RK:
2207
|
|
|
|
6-hydroxymethyl-7,8-dihydropterin_diphosphate + 4-aminobenzoyl_glutamic_acid <=> diphosphate + 7,8-dihydrofolate
|
2.5.1.15
dihydropteroate synthase
|
–
|
|
|
BRENDA:
BS356230
SABIO-RK:
9563
|
|
|
|
7,8-dihydrofolate + NAD+ <=> folate + NADH + H+
|
1.5.1.3
dihydrofolate reductase
|
–
|
K
|
|
KEGG:
R02235
|
|
|
|
uracil_in_tRNA + GTP + taurine + H2O + 5,10-methylenetetrahydrofolate + acceptor <=> 5-taurinomethyluridine_in_tRNA + GDP + phosphate + 7,8-dihydrofolate + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-16822
|
|
|
|
2-thiouridine34_in_tRNA + GTP + 5,10-methylenetetrahydrofolate + glycine + H2O + acceptor <=> 5-carboxymethylaminomethyl-2-thiouridine34_in_tRNA + GDP + phosphate + 7,8-dihydrofolate + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18710
|
|
|
|
tRNA_uridine34 + GTP + 5,10-methylenetetrahydrofolate + glycine + H2O + acceptor <=> 5-carboxymethylaminomethyluridine34_in_tRNA + GDP + phosphate + 7,8-dihydrofolate + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN0-7068
|
|
|
|
2-thiouridine34_in_tRNA + 5,10-methylenetetrahydrofolate + NH3 + GTP + H2O <=> 5-aminomethyl-2-thiouridine34_in_tRNA + 7,8-dihydrofolate + GDP + phosphate
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-7083
|
|
|
|
5,10-methylenetetrahydrofolate + dCTP <=> 7,8-dihydrofolate + deoxy-5-methylcytidine_5''-triphosphate
|
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
|
|
|
BRENDA:
BS289537
|
|
|
|
5,10-methylenetetrahydrofolate + uridine_5''-phosphate <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319736
|
|
|
|
tetrahydrofolate + 2''-deoxyuridine_5''-monophosphate <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319738
|
|
|
|
7,8-dihydrofolate + reduced_acetylpyridine_adenine_dinucleotide <=> tetrahydrofolate + 3-acetylpyridine_adenine_dinucleotide
|
1.5.1.3
dihydrofolate reductase
|
–
|
|
|
BRENDA:
BS259282
|
|
|
|
tetrahydrofolate + deoxyuridine <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319737
|
|
|
|
anthranilate + tetrahydrofolate + O2 <=> 3-Hydroxyanthranilate + 7,8-dihydrofolate + H2O2
|
1.14.16.3
anthranilate 3-monooxygenase
|
–
|
|
|
BRENDA:
BS288192
|
|
|
|
GTP + 7,8-dihydropteroate + L-glutamate <=> GDP + phosphate + 7,8-dihydrofolate
|
6.3.2.12
dihydrofolate synthase
|
–
|
|
|
BRENDA:
BS431
|
|
|
|
dATP + 7,8-dihydropteroate + L-glutamate <=> dADP + phosphate + 7,8-dihydrofolate
|
6.3.2.12
dihydrofolate synthase
|
–
|
|
|
BRENDA:
BS428
|
|
|
|
7,8-dihydrofolate + H2O <=> 7,8-dihydropteroate + L-glutamate
|
3.4.17.11
glutamate carboxypeptidase
|
–
|
|
|
BRENDA:
BS361735
|
|
|
|
ITP + 7,8-dihydropteroate + L-glutamate <=> IDP + phosphate + 7,8-dihydrofolate
|
6.3.2.12
dihydrofolate synthase
|
–
|
|
|
BRENDA:
BS430
|
|
|
|
UTP + 7,8-dihydropteroate + L-glutamate <=> UDP + phosphate + 7,8-dihydrofolate
|
6.3.2.12
dihydrofolate synthase
|
–
|
|
|
BRENDA:
BS429
|
|
|
|
methylenetetrahydropteroylglutamate + dUMP <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451873
|
|
|
|
5,10-methenyltetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS399200
|
|
|
|
N10-formyltetrahydropteroylglutamate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> 7,8-dihydrofolate + 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS419230
|
|
|
|
5,10-methylenetetrahydrofolate + CTP <=> 7,8-dihydrofolate + 5-methylcytidine_5''-triphosphate
|
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
|
|
|
BRENDA:
BS289539
|
|
|
|
folate + NADPH + H+ <=> 7,8-dihydrofolate + tetrahydrofolate + NADP+
|
1.5.1.33
pteridine reductase
|
–
|
|
|
BRENDA:
BS394857
|
|
|
|
7,8-dihydrofolate + NADP+ + H+ <=> tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
|
–
|
|
|
BRENDA:
BS408226
|
|
|
|
ATP + 7,8-dihydrofolate + L-glutamate <=> ADP + phosphate + 7,8-dihydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS453748
|
|
|
|
ATP + 7,8-dihydrofolate + L-glutamate <=> ADP + phosphate + 7,8-dihydropteroyl-gamma-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS453737
|
|
|
|
ATP + 7,8-dihydropteroate + L-glutamate <=> ADP + 7,8-dihydrofolate
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS369060
|
|
|
|
5,10-methylenetetrahydrofolate + 2''-deoxycytidine_5''-monophosphate <=> 7,8-dihydrofolate + CMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319742
|
|
|
|
5,10-methylenetetrahydrofolate + CMP <=> 7,8-dihydrofolate + 5-methylcytidylate
|
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
|
|
|
BRENDA:
BS289538
|
|